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Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 178-182 doi: 10.1007/s11684-016-0442-2

Abstract:

Metastasis-associated gene 1 (MTA1) controls a series of biological processes in tumor progressionTumor progression is a complex process regulated by a gene network.The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecularnetwork and its cooperative genes by further exploring the biological functions of this gene.GO and KEGG pathway analyses were conducted with DAVID and gene network analysis via STRING and Cytoscape

Keywords： metastasis-associated gene 1     colon cancer     bioinformatics    

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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10−6) afterFurther bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissuesidentified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1<

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellular    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (nburden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines) and human embryonic kidney 293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1gene was amplified by polymerase chain reaction (PCR) and cloned into pGL3-basic vector and pEGFP-1 vectorcell lines may be due to loss of transcription activity of XAF1 promoter.

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcomademonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1decreased the metastasis of osteosarcoma.

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associatedBHK-21 cells, then the recombinant AAV genome was replicated and packaged with the helper virus HSV1-MC3T3-E1 cells were infected with rAAV2-tet-off-bFGF.tet-off-bFGF successfully constructed was 1.8×10 vector genomes/mL, and the virus could infect MC3T3-E1In MC3T3-E1 cells treated with Dox, the expression levels of exogenous bFGF and osteogenic factors declined

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract:

Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development.In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO).The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice.Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 93-98 doi: 10.1007/s11684-007-0018-2

Abstract: lymphomas and reactive lymph node hyperplasia, and to perform an initial bioinformatic analysis on a novel genelymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with GeneInitial bioinformatic analysis was then performed on a novel gene named KIAA0372, whose function hasUsing Gene Expression Chips, many differentially expressed genes were uncovered.

Keywords： bioinformatic analysis     functional     KIAA0372     detection     Microarray    

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Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: peripheral blood monocular cells (PBMCs) and the association of the inhibitory effect with TNF-α-308 geneGene polymorphism at A-G site 308 in the promoter region of TNF-α gene was detected in 42 these patients and treated first with lipopolysaccharides (LPS) and then with different doses of TP (1,The results showed that TNF-α level in the supernatants of TP (1 ng/mL)-treated PBMCs wasIt was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-α

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 247-253 doi: 10.1007/s11684-010-0027-4

Abstract: Tumor metastasis is the leading cause of death for gastric cancer.Metastasis is the main reason for the failure of clinical treatment for gastric cancer.In order to find metastasis-related genes and abnormal signal transduction pathway of high-invasive gastricfrom gastric cancer were investigated by the Gene Cluster with Literature Profiles (GenCLip) analysisBesides, gene sequences, specific keywords or gene regulatory networks were further searched by GenCLiP

Keywords： gastric carcinoma     metastasis     signal transduction     gene chips    

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Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern

Lizhe Ai, Yaqin Yu, Xiaoli Liu, Chong Wang, Jieping Shi, Hui Sun, Qiong Yu

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 113-117 doi: 10.1007/s11684-014-0310-x

Abstract: association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1&This study aimed to examine the association of this gene with PTC in Chinese.In conclusion, rs944289 was associated with an increased risk of PTC in the Han population of Northernno clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.

Keywords： NKX2-1     papillary thyroid carcinoma     the Han population of Northern China     association    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis.However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlyHere, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma    

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RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancerand loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasisMechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRASCollectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 212-218 doi: 10.1007/s11684-016-0438-y

Abstract: Gene therapy might be the ultimate strategy for the disease.However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safetySelf-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring lowA strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced intoOur study provides a potential gene therapy method for hemophilia B.

Keywords： hemophilia B     AAV8     hFIX     gene therapy    

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Title Author Date Type Operation

Bioinformatic exploration of MTA1-regulated gene networks in colon cancer

Chunxiao Li,Haijuan Wang,Feng Lin,Hui Li,Tao Wen,Haili Qian,Qimin Zhan

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Journal Article

Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated withTNF-alpha-308 gene polymorphisms in rheumatoid arthritis patients

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Journal Article

Are the SNPs of NKX2-1 associated with papillary thyroid carcinoma in the Han population of Northern

Lizhe Ai, Yaqin Yu, Xiaoli Liu, Chong Wang, Jieping Shi, Hui Sun, Qiong Yu

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1

Journal Article

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Journal Article